Abstract
A phytochemical investigation on 90% methanol extract from the leaves of Juglans sigillata led to the isolation of three new triterpenoids, jugsigiloids A–C (1–3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-inflammatory activities against COX-1 and COX-2 and radical scavenging potential using DPPH test. As a result, triterpenoid 1 exhibited selective inhibition on COX-2 (93.2%) at the concentration of 100 μM and significant DPPH scavenging activity (IC50 = 41.6 μM) comparable with positive control Trolox (IC50 = 42.8 μM).
Graphical Abstract
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Disclosure statement
No potential conflict of interest was reported by the author(s).