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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 8
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Tirucallane-type triterpenoid from the stem bark of Chisocheton lasiocarpus and its cytotoxic activity against MCF-7 breast cancer cells

Nurlelasaria Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-9317-2607View further author information
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Samuel San Paruliana Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0003-4421-7685View further author information
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Al Arofatus Nainia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0001-7010-4110View further author information
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Erina Hilmayantia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, Indonesia;b Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka560-0043, JapanORCID Iconhttps://orcid.org/0000-0003-0251-5916View further author information
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Kindi Farabia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0001-5552-3827View further author information
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Desi Harnetia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-8120-7892View further author information
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Darwatia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0001-7596-4435View further author information
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Tri Mayantia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0003-1628-6288View further author information
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Rani Maharania Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, Indonesia;c Central Laboratory, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-4832-7227View further author information
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Tati Herlinaa Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, IndonesiaORCID Iconhttps://orcid.org/0000-0003-0007-8695View further author information
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Unang Supratmana Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor45363, Indonesia;c Central Laboratory, Universitas Padjadjaran, Jatinangor45363, IndonesiaCorrespondence[email protected]
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Risyandi Anward Herbal Medicine Research, Department of Pediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, Semarang50272, IndonesiaORCID Iconhttps://orcid.org/0000-0002-5520-8461View further author information
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Sofa Fajriahe Research Center for Chemistry, National Research and Innovation Agency (BRIN) Kawasan PUSPIPTEK Serpong Tangeran Selatan, Banten15314, IndonesiaORCID Iconhttps://orcid.org/0000-0002-1758-2102View further author information
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Mohamad Nurul Azmif School of Chemical Sciences, Universiti Sains Malaysia, Minden11800, MalaysiaORCID Iconhttps://orcid.org/0000-0002-2447-0897View further author information
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Thomas Prescottg Royal Botanic Gardens, Kew, RichmondTW9 3AB, United KingdomORCID Iconhttps://orcid.org/0000-0002-3039-7067View further author information
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Yoshihito Shionoh Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka997-8555, JapanORCID Iconhttps://orcid.org/0000-0002-9303-0182View further author information
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Pages 803-809 | Received 01 Sep 2022, Accepted 30 Oct 2022, Published online: 21 Nov 2022
 
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Abstract

Chisocarpene A (1) is a new tirucallane-type triterpenoid together with odoratone (2) and 24-methylenecycloartanol (3), isolated from the stem bark of Chisocheton lasiocarpus. The chemical structures of compounds 1–3 were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay. Compound 1 showed the most potent activity (IC50 26.56 ± 1.01 µM) and was two-fold more active than the positive control.

Acknowledgments

We thank to Mrs. Kansi Haikal and Ms. Nurul Fadhilah at the Central Laboratory, Universitas Padjadjaran, Indonesia for HRTOF-MS measurements and cytotoxic assay.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This investigation was financially supported by RKDU grant [No. 2203/UN6.3.1/PT.00/2022] by Nurlelasari from Universitas Padjadjaran and Academic Leadership Grant [No. 1959/UN6.3.1/PT.00/2022] by Unang Supratman.

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