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Articles

Two new compounds from the Hainan Soft Corals Sinularia tumulosa and Sinularia depressa with their anti-inflammatory or cytotoxic activities

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Pages 949-956 | Received 22 Nov 2022, Accepted 13 Feb 2023, Published online: 22 Feb 2023
 

Abstract

The detailed chemical investigations of the South China Sea soft corals Sinularia tumulosa and Sinularia depressa, yielded two new compounds, namely tumulosterol A (1) and 11’-hydroxy-α-tocopherylquinone (3), along with four related known ones (2, 57). Their structures were determined by extensive spectroscopic analysis and comparison with the spectral data previously reported in the literature. In bioassays, compound 1 displayed significant cytotoxic effects against H1975 and MDA-MB-231 cells with IC50 values of 6.0 and 6.3 µM, respectively. In addition, compound 3 exhibited interesting inhibitory effect on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 cells with IC50 value of 9.5 µM.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research work was financially supported by the National Natural Science Foundation of China [No. 81991521], the SKLDR/SIMM Project [No. SIMM2103ZZ–06]. We thank Prof. X.-B. Li from Hainan University for the taxonomic identification of the soft coral materials.

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