Compounds isolated from the pericarp of Zanthoxylum bungeanum and inhibitory activity against LPS-induced NO production in RAW264.7

Abstract

Seventeen compounds were isolated and identified from the ethyl acetate part of Zanthoxylum bungeanum Maxim., including one new compound 18-acetyloxyneocryptotanshinone (1) and 16 known compounds (2–17). Their structures were elucidated by extensive spectroscopy. The absolute configuration of 1 was confirmed by electronic circular dichroism (ECD). All compounds were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, of which 1 and 10 exhibited the most significant inhibitory effect, with IC₅₀ of 17.29 and 10.27 μM, respectively.

Graphical Abstract

Keywords:

• Zanthoxylum bungeanum
• Rutaceae
• isolation
• 18-acetyloxyneocryptotanshinone
• NO production inhibitor

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the Research Foundation for Administration of Traditional Chinese Medicine of Sichuan Province [2020HJZX002], the National Natural Science Foundation of China [82073734], and the Fundamental Research Funds for Central Universities [2682021CX085].