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Articles

Total syntheses of pongaflavone and its natural analogues

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Pages 1085-1096 | Received 17 Sep 2022, Accepted 16 Mar 2023, Published online: 23 Mar 2023
 

Abstract

The efficient total synthesis of anti-tumor natural product pongaflavone (1) was described starting from commercially available 2,4-dihydroxyacetophenone (9) via seven steps and in 16% overall yield. Its two natural analogues pongachromene (2) and 7,8-(2”,2”-dimethylpyrano)-5,3’,4’-trihydroxy-3-methoxyflavone (3) were also synthesized following the similar procedure with the yields of 11% and 18%, respectively. Their preliminary anti-tumor activities were evaluated by the inhibition effect on A549 cells. The result showed that this kind of natural products exhibited different levels of anti-tumor activity. Among them, pongachromene (2) displayed the best anti-tumor activity.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The work was financially supported by the National Natural Science Foundation of China [NSFC 82003619]; Sichuan Science and Technology Program [2023NSFSC0609, 22NZZH031].

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