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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 11
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New steroid produced by Periconia pseudobyssoides K5 isolated from Toona sureni (Meliaceae) and its heme polymerization inhibition activity

Azmi Azharia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, Indonesia;b Department of Chemistry Education, Faculty of Tarbiyah and Teacher Training, Institut Agama Islam Negeri Syekh Nurjati Cirebon, Cirebon45132, IndonesiaORCID Iconhttps://orcid.org/0000-0003-1695-6528View further author information
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Al Arofatus Nainia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0001-7010-4110View further author information
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Desi Harnetia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-8120-7892View further author information
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Asri Peni Wulandaric Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-8505-9188View further author information
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Yeni Mulyania Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-2535-3692View further author information
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Sari Purbayaa Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-6920-0583View further author information
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Aprilia Permata Saria Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0003-4578-1923View further author information
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Galih Bayu Pratamaa Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-7180-9910View further author information
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Risyandi Anward Herbal Medicine Research, Department of Pediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, Semarang50272, IndonesiaORCID Iconhttps://orcid.org/0000-0002-5520-8461View further author information
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Mohammad Fajara Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-2224-2356View further author information
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Fajar Fauzi Abdullaha Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0002-1647-453XView further author information
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Kindi Farabia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaORCID Iconhttps://orcid.org/0000-0001-5552-3827View further author information
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Unang Supratmana Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java45363, Indonesia;e Central Laboratory, Universitas Padjadjaran, Jatinangor, West Java45363, IndonesiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1104-2321View further author information
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Pages 1117-1124 | Received 25 Nov 2022, Accepted 21 Mar 2023, Published online: 05 Apr 2023
 
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Abstract

A new ergostane-type steroid named (22E)-3α,6α,9α-ergosta-7,22-diene-3,6,9-triol (1), along with six known steroids 5α,8α-epidioxy-24-ethyl-cholest-6-en-3β-ol (2), ergosterol-5,8-peroxide (3), cerevisterol (4), isocyathisterol (5), 6β-hydroxystigmast-4-en-3-one (6), 6β-hydroxy-4-campesten-3-one (7), were isolated from the fermented unpolished rice media by Periconia pseudobyssoides K5 (Periconiaceae), an endophytic fungus from medicinal plant Toona sureni (Meliaceae). The fermentation takes at 28 ± 2 °C for 30 days. The structure of new steroid (1) was elucidated by extensive spectroscopic measurements (IR, HR-ESI-TOFMS, and 1D and 2D NMR) analyses. The isolated compounds (1–7) were evaluated for heme polymerization inhibition assay (HPIA). The IC50 HPIA value of 1 is 8.24 ± 0.03 mg/ml.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research was financially supported by the Academic Leadership Grant [No: 1959/UN6.3.1/PT.00/2023 by Unang Supratman].

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