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Abstract
One new sesquiterpene, (6S,7R,11S)-13-carboxy-1(10)-en-dihydroartemisinic acid (1), together with three known sesquiterpenes, ainsliaea acid B (2), mongolicumin B (3), and 11β,13-dihydroxydeacetylmatricarin (4) were isolated from Taraxacum mongolicum Hand.-Mazz. The structures were established on the basis of UV, IR, HR-ESI-MS, 1D and 2D NMR spectroscopy, ECD spectroscopy, and X-ray diffraction analysis. Compound 1 was found to have potential anti-inflammatory activity and could reduce LPS-induced NO levels in murine macrophage, with inhibitory rate of 37%.
Acknowledgments
The authors are grateful for the financial support from the CAMS Innovation Fund for Medical Sciences (CIFMS).
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
We are grateful for the financial support from the CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-I2M-1-028].