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Abstract
One chromone (1), together with four known alkaloids, were isolated from the mangrove endophytic fungus Aspergillus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses. Compound 1 showed strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 4.094 ± 0.8 μM, which was better than positive drug indomethacin (IC50=35.8 ± 0.5 μM).
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
The authors gratefully acknowledge the grants from National Natural Science Foundation of China [No. 41876153] and Guangdong Marine Economy Development Special Project [No. GDNRC[2022]35].