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Abstract
Two new alkaloids, spongimides A (1) and B (2), along with five known ones (3–7), were isolated from the marine sponge Spongia sp. The structures of 1 and 2 were determined by the spectroscopic methods (UV, IR, MS, and NMR) and X-ray diffraction analysis. Compounds 1, 3, and 4 were the first examples of 2,4-imidazolidinediones isolated from this genus. In addition, the cytotoxic and antibacterial activities of compounds 1 and 2 were also evaluated.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was supported by the Department of Natural Resources of the Guangdong Province [No. GDNRC [2021] 48], the National Key Research and Development Program of China [No. 2022YFC2804100], the National Natural Science Foundation of China [Nos. 41876145 and 81874292], and the Science and Technology Planning Project of Guangzhou [No. 202102010066].