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Articles

A new terrein dimer and a new meroterpene from the mangrove endophytic fungus Lichtheimia sp.

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Pages 1068-1075 | Received 13 Jan 2023, Accepted 28 Mar 2023, Published online: 12 Apr 2023
 

Abstract

A new terrein dimer named lichtheicol A (1) and a new meroterpene named lichtheiterpene A (2), were isolated from the mangrove endophytic fungus Lichtheimia sp. J2B1, together with 10 known compounds (3–12). The planar structures and absolute configurations of 1 and 2 were established by a combination of extensive spectroscopic data analyses and electronic circular dichroism (ECD) calculations. Compounds 4 and 5 exhibited marked inhibitory effects against butyrylcholinesterase (BuChE) with IC50 values of 0.71 and 0.53 μM, respectively.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by grants from the National Natural Science Foundation of China [U20A2001 and 42261144740].

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