A new chromanone acid derivative from the nut oil resin of Calophyllum inophyllum

Abstract

One novel chromanone acid derivative, namely inocalophylline C (1), together with one known compound calophyllolide (2), were isolated from the methanolic extract of nut oil resin of Calophyllum inophyllum L., a medicinal plant widely distributed in Vietnam. The isolated compound structures were elucidated by spectroscopic methods and the absolute configuration of 1 was established by the single-crystal X-ray crystallography as ethyl (R) 3-((2 R,3R,6R)-4-hydroxy-2,3-dimethyl-6-((R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)-6-(3-methylbut-2-en-1-yl)-5,7-dioxo-3,5,6,7-tetrahydro-2H-chromen-8-yl)-3-phenylpropanoate.

Graphical Abstract

Keywords:

• Clusiaceae
• Calophyllum inophyllum
• resin
• nut oil
• inocalophyllin C
• chromanone acid derivative

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The financial support from the Nagai Foundation Tokyo for this project is deeply acknowledged. The author also wishes to acknowledge the National University of Singapore for providing the research environment.