Phloroglucinol derivatives with α-glucosidase inhibitory activities from Syzygium fluviatile

Abstract

Four new phloroglucinol derivatives (1 − 4) were isolated from the leaves of Syzygium fluviatile. Their structures were elucidated by means of extensive spectroscopic data. Among them, compounds 1 and 3 showed significant inhibitory activity against α-glucosidase with IC₅₀ values of 10.60 and 5.07 µM, respectively. The structure-activity relationship was also discussed briefly.

Keywords:

• Syzygium fluviatile
• phloroglucinol
• α-glucosidase

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [No. 31560098 and 81522044].