Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp.

Abstract

Two oxygenated ergostane-type steroids including one new compound, 3β-hydroxy-5α,6β-methoxyergosta-7,22-dien-15-one (1) along with a known analogue ergosta-6,22-dien-3β,5α,8α-triol (2) were isolated from the crude extracts of the marine sponge-derived fungus Aspergillus sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound 1 was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound 1 exhibited antibacterial activity against Staphylococcus aureus.

Keywords:

• Steroid
• sponge
• fungus
• antibacterial activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was financially supported by the National Natural Science Foundation of China [42176101, 42006104], the Zhejiang Basic Public Welfare Research Project [LGF22B020002], Ningbo Key Science and Technology Development Program [2021Z046], Public Welfare Foundation of Ningbo City [2021S059], the National 111 Project of China [D16013], the Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund, the Scientific Research Foundation of Graduate School of Ningbo University [IF2021086].