Two new bibenzyl methylglucosides as SIRT3 activators obtained through microbial transformation

Abstract

Microbial transformation of dihydroresveratrol (DHRSV) using Beauveria bassiana has produced two new methylglucosylated derivatives of DHRSV (1 and 2), whose structures were characterized as 4′-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (4′-O-MG DHRSV, 1) and 3-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (3-O-MG DHRSV, 2) on the basis of spectroscopic methods. They showed moderate SIRT3 agonistic activity, and compound 2 exhibited the best deacetylation of 406.63% at 10 μM. The activity of 2 increased by 3.12-fold compared with that of DHRSV, since 2 performed better in molecular docking assay (GScore −8.445).

Keywords:

• Bibenzyls
• microbial transformation
• Beauveria bassiana
• methylglucosylation
• SIRT3 agonist

Acknowledgements

We are grateful to the Department of Instrumental Analysis of our institute for measurement of the IR, NMR, and HRESIMS data. We acknowledge Topscience for providing molecular docking services.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research work was financially supported by National Key Research and Development Program of China [grant nos. 2020YFA0908003 and 2018YFA0901900] and CAMS Innovation Fund for Medical Sciences [no. CIFMS2021-I2M-1-029].