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Abstract
Phytochemical investigation on the aerial parts of Salvia deserta led to the isolation of eight new pentacyclic triterpenoids including three oleanane- (1 − 3) and five ursane-type (4 − 8) triterpenoids, whose structures were elucidated based on extensive spectroscopic analysis and quantum chemical calculation. Weak immunosuppressive potency was observed for compounds 1, 2, and 4 − 8 via inhibiting the secretion of cytokines TNF-α and IL-6 in LPS-induced macrophages RAW264.7 at 20 μM. In addition, compounds 1, 2, and 4 − 6 exhibited moderate protective activity on t-BHP-induced oxidative injury in HepG2 cells.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by the State Key Program of National Natural Science Foundation of China [21937006], the National Natural Science Foundation of China [82204245], the Natural Science Foundation of Sichuan [2022NSFSC1456 and 2022NSFSC1362], and the China Postdoctoral Science Foundation [2021M690487 and 2022MD723713].