Structurally diverse triterpenoid alkaloids from Buxus rugulosa

Abstract

Four new nortriterpenoid alkaloids, namely buxrugulines E–H (1–4), along with five known ones (5–9), were isolated from the twigs and leaves of Buxus rugulosa. Their structures were identified based on extensive NMR data and MS spectroscopic analyses. Our bioassays revealed that compounds 5, 6 and 8 exhibited potent cytotoxicity in vitro against MCF-7 cell lines, with IC₅₀ values ranging from 6.70 to 11.00 μM, respectively.

Keywords:

• Buxus rugulosa
• nortriterpenoid alkaloid
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the “Double First-Class” University Project (CPU2018GY08) and the Drug Innovation Major Project (2018ZX09711-001-007).