Bioactive neolignan, iridoid and flavonoid glycosides from the leaves of Vaccinium bracteatum

Abstract

Two neolignan glycosides including a new one (1), along with seven iridoid glycosides (3 − 9) and nine flavonoid glycosides (10 − 18), were isolated from the leaves of Vaccinium bracteatum. Their structures were established mainly on the basis of 1D/2D NMR and ESIMS analyses, as well as comparison to known compounds in the literature. The structure of 1 with absolute stereochemistry was also confirmed by chemical degradation and ECD calculation. Selective compounds showed antiradical activity against ABTS and/or DPPH. Moreover, several isolates also suppressed the production of ROS in RAW264.7 cells and exerted neuroprotective effect toward PC12 cells.

Keywords:

• Ericaceae
• Vaccinium bracteatum
• lignan glycoside
• iridoid glycoside
• flavonoid glycoside
• antioxidant activity
• cell protective activity

Acknowledgements

Funding support from the Natural Science Foundation of Shandong Province [No. JQ201721] is greatly acknowledged. We thank Guo-hua Ye for the authentication of the plant materials.

Disclosure statement

No potential conflict of interest was reported by the authors.