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Research Articles

Triterpenoids from Juglans mandshurica with anti-hyaluronidase activities

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Pages 773-779 | Received 30 Dec 2023, Accepted 04 Mar 2024, Published online: 12 Mar 2024
 

Abstract

Phytochemical study on 90% ethanol extract from the green walnut husks of Juglans mandshurica Maxim. resulted into the isolation of three undescribed triterpenoids, juglansmanoids A–C (13). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-hyaluronidase activities. As a result, triterpenoid 1 exhibited potent anti-hyaluronidase activity (IC50 = 9.78 μg/ml) three times more than the positive control drug oleanolic acid (IC50 = 40.12 μg/ml).

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The author(s) reported there is no funding associated with the work featured in this article.

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