Excelxylin A: a new seco A-ring tirucallane triterpenoid from the stem bark of Dysoxylum excelsum

Abstract

A new seco-A tirucallane triterpenoid named excelxylin A (1), along with two known seco-A triterpenoids (2–3), were isolated from the n-hexane extract of Dysoxylum excelsum (Spreng.) Blume ex G.Don stem bark. The structure and stereochemistry configuration of compounds 1–3 was established by NMR, IR, and HR-ESI-MS spectroscopic data analyses and comparison of their NMR data with literatures. The compounds exhibited the carbon framework for seco-A ring tirucallane triterpenoid, first reported in the Dysoxylum genus. All compounds were tested for their cytotoxicity against human cervical HeLa cells.

Keywords:

• Dysoxylum excelsum
• seco-A ring tirucallane
• excelxylin A
• cytotoxic activity

Disclosure statement

No potential conflict or interest was reported by the author(s).

Additional information

Funding

The authors are grateful for the facilities provided by Universitas Padjadjaran, Indonesia through the Academic Leadership Grant, No: 1959/UN6.3.1/PT.00/2023 awarded to Unang Supratman.