![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Nine jatrophane diterpenoids were isolated from the whole plant Euphorbia helioscopia, including two new ones, helioscopnins A (1) and B (2). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 1, 3, 4, 5, 8, and 9 significantly increased autophagic flux.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
Financial support for this study was provided by National Natural Science Foundation of China (82360687 and 32170988), Guizhou Provincial Science and Technology Project (ZK [2022]393), Guizhou Province High Level Innovative Ten Level Talent Project (QKH [2023]002), Guizhou Provincial Natural Science Foundation ([2022]4017 and [2021]4029), Provincial College Student Innovation and Entrepreneurship Project (S202210660144)