The Structure of Physalin T from Physalis alkekengi var. francheti

Tatsuo Yamamoto Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan

Bunsho Makino Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan; Kampo and Pharmacognosy Laboratory, Tsumura and Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-1192, Japan

Hatsuo Yamamura Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan

Shuki Araki Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan

Yasuo Butsugan Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan

Kazuki Saito Yokoyama CytoLogic Project, ERATO, Japan Science and Technology Corporation, c/o Tsukuba Research Consortium, 5-9-1 Tokodai, Tsukuba, 300-2635, Japan

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Abstract

A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on ¹H and ¹³C NMR spectral studies the structure was assigned as 2,3-dihydrophysalin D, i.e., 5α,6β-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is the first example of a natural physalin possessing a saturated ring A moiety. The structure was confirmed by the chemical transformation from the known physalin D (2) to physalin T.

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The Structure of Physalin T from Physalis alkekengi var. francheti

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