Two new and four known polyphenolics obtained as new cell-cycle inhibitors from Rubus aleaefolius poir

Two new polyphenolics, rubuphenol (1) and sanguiin H-2 ethyl ester (2), were isolated together with ellagic acid (3), ethyl gallate (4), 1,2,3,4,6-penta-O-galloyl-g -D-glucopyranose (5) and 1,2,3,6-tetra-O-galloyl-g -D-glucopyranose (6) as new cell-cycle inhibitors from Rubus aleaefolius by bioassay-guided separation procedure and the structures of 1 and 2 were elucidated by spectroscopic method. Compounds 1 - 6 inhibited the cell cycle progression of tsFT210 cells at the G₀/G₁ phase with the MIC values of 14.6 w M (1), 22.1 w M (2), 10.3 w M (3), 7.8 w M (4), 7.9 w M (5) and 6.6 w M (6).

Keywords:

• Rosacae
• Rubus Aleaefolius
• Rubuphenol
• Sanguiin H-2 Ethyl Ester
• Ellagitannin
• Gallotannin
• Cell Cycle Inhibitor