Cytotoxic macrocyclic trichothecenes from the mycelia of calcarisporium arbuscula preuss

Neng-Jiang Yu Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, China

Shun-Xing Guo Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, China

Hai-Yan Lu Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, China

A new cytotoxic macrocyclic trichothecene calcarisporin B1 ( 1 ), and two known compounds roridin H ( 2 ) and roridin J ( 3 ) were isolated from the cultured mycelia of Calcarisporium arbuscula Preuss. The structure of 1 was determined to be 8 f -acetoxy roridin H on the basis of spectral data. The cytotoxic activities of 1 - 3 were evaluated in vitro .

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Cytotoxic macrocyclic trichothecenes from the mycelia of calcarisporium arbuscula preuss

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