A cytotoxic diterpenoid and antifungal phenolic compounds from Frullania muscicola steph

A novel ent -labdane type diterpenoid, muscicolone ( 1 ), as well as two bibenzyls ( 2 , 3 ) and four flavonoids ( 4 - 7 ) were isolated from the liverwort Frullania muscicola Steph. Their structures were established by analysis of the spectral data of IR, UV, 1D-, 2D-NMR, and ORD. The stereostructure of 1 was confirmed by X-ray crystallographic analysis. Bioassay experiments showed that compound 3 and 4 have potent inhibitory effects against some fungi while 1 showed cytotoxic effects to some human tumor cells.

Keywords:

• Hepaticae
• Liverworts
• Frullania Muscicola
• Diterpenoid, Bibenzyls
• Flavonoids
• Cytotoxic, Anti-fungi