Terminoside A, a new triterpene glycoside from the bark of Terminalia arjuna inhibits nitric oxide production in murine macrophages

Abstract

Terminoside A (1), a new oleanane-type triterpene was isolated from the acetone fraction of the ethanolic extract of stem bark of Terminalia arjuna. The structure was established as olean-1α,3β,22β-triol-12-en-28-oic acid-3β-D-glucopyranoside. On the basis of spectral data and chemical reactions, terminoside A, potently inhibited nitric oxide (NO) production and decreased inducible nitric oxide synthase (iNOS) levels in lipopolysaccharide-stimulated macrophages.

Keywords:

• Triterpene glycoside
• Terminoside A
• Nitric oxide

Acknowledgements

The authors owe their thanks to the Director, Faculty of Pharmacy, Meijo University, Nagoya, Japan for providing ¹H, ¹³C and 2D NMR and mass spectral data. Two of us, A.A. and G.K., are thankful to the Hamdard National Foundation Fellowship, and the Council of Scientific & Industrial Research, New Delhi, respectively, for providing financial assistance.