A new cerebroside from Uvaria tonkinensis var. subglabra

Abstract

A new cerebroside, subglain A (1), together with five known compounds (2–6) have been isolated from the stems of Uvaria tonkinensis var. subglabra. The structure of 1 has been determined to be 1-O-β-D-glucopyranosyl-(2S,3S,4R,8Z,2′R)-2-[N-(2′-hydroxytetracosanyl)-N-(1″,2″-dihydroxyethyl)-amide]-8-tetradecene-1,3,4-triol by spectroscopic evidence. The known compounds were identified as schisandriside (2), erythritol (3), β-D-glucopyranose (4), kaempferol-3,7-O-α-L-dirhamnoside (5), and (+)-lyoniresinol (6).

Keywords:

• Uvaria tonkinensis var. subglabra
• Annonaceaes
• Subglain A
• Cerebroside

Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (no. 39970084) and from the Chinese Doctoral Grants of the Ministry of Science and Technology of China (no. 96-901-96-54). We thank Dr Guang-zhong Tu, Beijing Institute of Microchemistry Research, for NMR measurements.