Triterpenes from Tripterygium wilfordii Hook

J.-H. Yang Yunnan University, School of Pharmacy, Center for Advanced Studies of Medicinal and Organic Chemistry, Kunming,Yunnan, 650091, China

S.-D. Luo State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Kunming, Yunnan, 650204, China

Y.-S. Wang State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Kunming, Yunnan, 650204, China

J.-F. Zhao Yunnan University, School of Pharmacy, Center for Advanced Studies of Medicinal and Organic Chemistry, Kunming,Yunnan, 650091, China

H.-B. Zhang Yunnan University, School of Pharmacy, Center for Advanced Studies of Medicinal and Organic Chemistry, Kunming,Yunnan, 650091, China

L. LI Yunnan University, School of Pharmacy, Center for Advanced Studies of Medicinal and Organic Chemistry, Kunming,Yunnan, 650091, ChinaCorrespondence[email protected] [email protected]

Abstract

Two new friedelane-type triterpenes, tripterfrielanons A (1) and B (2), along with six known triterpenoids, friedelin (3), canophyllal (4), canophyllalic acid (5), 3-oxo-29-hydroxyfriedelane (6), wilforlide A (7), wilforlide B (8), have been isolated from the EtOH extract of the roots of Tripterygium wilfordii Hook.f. Compounds 4, 5, 6 were isolated for the first time from this plant. The new triterpenes 1 and 2 exhibited mild cytotoxic activity against human Hela cell lines in vitro. The assay showed the IC₅₀ of 1 and 2 were 8.5 and 25 μg/mL, respectively.

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Acknowledgements

The authors thank Mr. Ji-Hua YU for collecting plant material and Mr. Shao-You LI for cytotoxicity assay.

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