Total synthesis and biological evaluation of (+)- and (−)-Butyl ester of rosmarinic acid

L.-J. Huang Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China

C.-H. Li Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China

Z.-M. Lu Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China

Z.-B. Ma Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China

D.-Q. Yu Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]

Abstract

An efficient method for the synthesis of the natural product (+)-(R)-butyl ester of rosmarinic acid (+)-(R)-1 and its enantiomer ( − )-(S)-1 has been developed by chemical resolution of its phenyl lactic acid precursors 4 with ( − )-menthol. Their antioxidative and anti-tumor activities were evaluated.

Keywords:

Acknowledgements

We wish to thank Dr. Hong-qi Xin and Professor Geng-tao Liu for in vitro testing.

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Total synthesis and biological evaluation of (+)- and (−)-Butyl ester of rosmarinic acid

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Total synthesis and biological evaluation of (+)- and (−)-Butyl ester of rosmarinic acid

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