Studies on chemical constituents from Ilex pubescens

Abstract

Two new phenolic glycosides, ilexpubsides A and B, along with four known lignan glycosides were isolated from the roots of Ilex pubescens. By spectral evidence, the structures of the new compounds were elucidated as 4-O-β-D-[6′-O-(4″-O-β-D-glucopyranosylvanilloyl)glucopyranosyl] vanillic acid (1) and syringinic 6′-O-β-D-xylopyranoside (2). The known compounds were identified to be liriodendrin (3), (-)-olivil (4), tortoside A (5) and (+)-cyclo-olivil (6). All compounds were first isolated from Ilex pubescens.

Keywords:

• Ilex pubescens
• Ilexpubside A
• Ilexpubside B
• Lignan glycoside

Acknowledgements

Thanks are given to the Department of Instrumental Analysis, Institute of Matera Medica, Chinese Academy of Medical Sciences and Peking Union Medical College for measuring the IR, MS and NMR spectral data. This work was supported by the National Natural Science Foundation of China (No. 20432030).