Two new cardenolides from the roots of Streptocaulon griffithii

Abstract

Two new cardenolides, 3β,5β,14β-trihydroxyl-card-16,20(22)-dienolide (1) and 3-O-β-d-glucopyranosyl-5β,14β-dihydroxyl-card-16,20(22)-dienolide (2), together with seven known compounds identified as digitogenin (3), 16-O-acetylgitoxigenin (4), periplogenin (5), 16-O-acetylperiplogenin (6), periplogenin digitoxoside (7), periplogenin-3-O-β-d-glucopyranoside (8) and periplogenin-3-O-β-d-glucopyranosyl-(1 → 4)-O-β-d-digitoxopyranoside (9) were isolated from the roots of Streptocaulon griffithii. Their structures were elucidated on the basis of spectroscopic data.

Keywords:

• Streptocaulon griffithii
• Asclepiadaceae
• Cardenolides
• 3β,5β,14β-Trihydroxyl-card-16,20(22)-dienolide
• 3-O-β-d-Glucopyranosyl-5β,14β-dihydroxyl-card-16,20(22)-dienolide

Acknowledgements

The authors are grateful to Mr. He-Bin Chen (Academy of Military Medical Sciences) for recording the NMR data.