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Journal of Asian Natural Products Research Volume 8, 2006 - Issue 7
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Original Articles

Effect of 17β-oestradiol and ginsenoside on osteoporosis in ovariectomised rats

Y.-S. Gong Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
J. Chen Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Q.-Z. Zhang Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
&
J.-T. Zhang Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]
Pages 649-656 | Received 12 Jan 2005, Accepted 23 May 2005, Published online: 01 Dec 2006
 
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Abstract

To study the anti-osteoporosis effects and mechanism of action of oestradiol (E2) and ginsenoside (tR), we measured the bone mineral densities (BMD) of lumbar vertebra and tibia and analysed the tibia histological morphological data, as well observed the activity and the number of osteoblasts and the activity of alkaline phosphatase (ALP) and the concentration of cAMP. Results showed that E2 (400 μg kg− 1 week− 1) and tR (10, 20, 30 mg kg− 1 day− 1) were able to countervail the decreasing in BMDs of lumbar vertebra and tibia induced by OVX in rats (P < 0.05); E2 (0.1 μmol l− 1) and ginsenoside Rg1 (1 μmol l− 1 and 10 μmol l− 1) were able to increase the number of osteoblasts, the activity of ALP and the concentration of intercellular cAMP in cultured osteoblast cells. The present findings suggest that E2 and tR have an anti-osteoporosis effect in ovariectomised rats.

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