Synthesis and bioactivity of novel caffeic acid esters from Zuccagnia punctata

Abstract

Synthesis of novel caffeic acid esters (1 and 2) was accomplished starting from appropriately substituted benzaldehydes (3 and 9). While compound 2 exhibited potent anti-oxidative activity in both the nitroblue tetrazolium and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging models, compound 1 showed moderate 5-lipoxygenase inhibitory activity.

Keywords:

• Zuccagnia punctata
• Synthesis
• Anti-oxidative
• 5-Lipoxygenase

Acknowledgements

The authors thank SIF of IISc in Bangalore for NMR spectral data, Mr. A.V. Krishna Raju for the bioactivity studies and Sri G. Ganga Raju, Chairman of Laila group, for his encouragement.