Microbial transformation of dehydrocostuslactone by Mucor polymorphosporus

Abstract

Biotransformation of dehydrocostuslactone (1) by Mucor polymorphosporus yielded four compounds, and their structures were identified as 11α,13-dihydrodehydrocostuslactone (2), 3α-hydroxy-11α,13-dihydrodehydrocostuslactone (3), 3β-hydroxy-4β,15,11α,13-tetrahydrodehydrocostuslactone (4) and 2β-hydroxyl-11α,13-dihydrodehydrocostuslactone (5), respectively, on the basis of their spectral data. Among them, compound 5 is a new compound.

Keywords:

• Biotransformation
• Dehydrocostuslactone
• Mucor polymorphosporus
• Aucklandia lappa

Acknowledgements

We thank the National Outstanding Youth Foundation by NSF of China (39925040) and Trans-Century Training Program Foundation for the Talents by the Ministry of Education for financial support.