Two new indole alkaloids from Naucleaofficinalis

W.-D. Xuan Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China; PLA 411th Hospital, Shanghai, 200083, China

H.-S. Chen Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, ChinaCorrespondence[email protected]

J.-L. Du Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China

S. Liang Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China

T.-Z. Li Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China

D.-G. Cai PLA 411th Hospital, Shanghai, 200083, China

Abstract

Two new indole alkaloids, naucleactonin A and B, along with two known compounds, naucleficine and nauclefidine, were isolated from the bark and wood of Nauclea officinalis, which has been used as an anti-inflammatory and anti-bacterial agent in folk medicine. Their chemical structures were elucidated by the spectral data, especially 1D and 2D NMR experiments.

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Two new indole alkaloids from Naucleaofficinalis

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Two new indole alkaloids from Naucleaofficinalis

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