A new flavonol from Sophora tonkinensis

Y.-H. Deng Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China

K.-P. Xu Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China

Y.-J. Zhou Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China

F.-S. Li Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China

G.-Y. Zeng Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China

G.-S. Tan Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, ChinaCorrespondence[email protected]

Abstract

A new flavonol, tonkinensisol, was isolated from the roots of Sophora tonkinensis, together with three known compounds named as bayin, vitexin and lupeol. Their structures were elucidated on the basis of spectroscopic evidence. Additionally, tonkinensisol showed moderate cytotoxicity suppressing the proliferation of HL-60 cells in vitro.

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Acknowledgements

We are very grateful to the National Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University P.R.C. for the measurement of NMR, and the Academy of Military Medical Sciences of China for the collection of MS and HRMS spectra.

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A new flavonol from Sophora tonkinensis

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A new flavonol from Sophora tonkinensis

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