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Abstract
Bioassay-guided fractionation of the ethanol extract of Senecio scandens led to the isolation of four new compounds 1–4. These compounds were obtained as tautomeric mixture of α/β epimers, but their structures were confirmed unambiguously by 1D and 2D NMR spectra and LC NMR technology. 1H NMR spectra of pure 1α and 1β were furnished by HPLC NMR technology. Compounds 1–4 exhibited moderate cytotoxicities against five tumor cell lines.
Acknowledgements
The authors are thankful to the Beijing Municipal Science & Technology Commission of China for the financial support. We also thank Mr Hongyan Liu for the cytotoxicity assay and Ms Xiaohua Ma for energy minimisation calculations.