Two forms of long-term potentiation induced by different compounds

Abstract

The purpose of this study was to investigate different forms of long-term potentiation (LTP) induced by different compounds. As shown in results, the influx of calcium via voltage-dependent calcium channels (VDCCs) was responsible for ( − )-clausenamide-induced LTP in hippocampus, while Rg1 induced LTP is mediated by the entry of calcium via N-methyl-d-aspartate glutamate (NMDA) receptor. The findings in the present study provide pharmacological basis for the nootropic mechanisms of these two compounds.

Keywords:

• Clausenamide
• Rg1
• Long-term potentiation
• Voltage-dependent calcium channels (VDCCs)
• N-methyl-d-aspartate glutamate receptor (NMDAR)

Notes

^‡ Current address: Clinical Psychopharmacology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, 333 Cassell Drive, Baltimore, MD 21224, USA.

^¶ Current address: Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA.

Additional information

Notes on contributors

X.-Y. Wang

‡ ‡ Current address: Clinical Psychopharmacology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, 333 Cassell Drive, Baltimore, MD 21224, USA.

S.-L. Liu

¶ ¶ Current address: Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA.