A new sesquiterpene lactone glucoside with inhibitory effect on K₅₆₂ cells from Ixeris sonchifolia (Bge) Hance

Abstract

A new minor sesquiterpene lactone glucoside, ixerin Z_A (1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-[6′-(p-metheoxyphenylacetyl)]-β-glucopyranoside on the basis of spectroscopic and chemical evidence. Compound 1 exhibited an inhibitory effect on K₅₆₂ cells.

Keywords:

• Ixeris sonchifolia
• Compositae
• Ixerin Z_A
• K₅₆₂ cells

Acknowledgements

We are grateful for the use of HRFAB-MS facilities at the Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.