A new nonadride derivative from mangrove fungus (strain No. k38)

Abstract

A new nonadride derivative, ( − )-1-hydroxybyssochlamic acid (1) and the known ( − )-byssochlamic acid (2) were isolated from mangrove fungus (strain No. k38) collected from the South China Sea coast. The structure and relative configuration of 1 were elucidated by spectral data and X-ray diffraction analysis. Primary bioassays showed that 2 had medium cytotoxic activity against HEp-2 and HepG2 Cells, and 1 exhibited weak activity.

Keywords:

• Fungus
• ( − )-1-Hydroxybyssochlamic acid
• X-ray diffraction
• Cytotoxic

Acknowledgements

We wish to acknowledge financial support from the National Natural Science Foundation of China (20072058), the 863 Foundation of China (2003AA624010), the Natural Science Foundation of Guangdong Province, China (021732), and the Star Lake Biotechnology Co., Inc., Zhaoqing, Guangdong, China.