Hederyne A, a new antimicrobial polyacetylene from galls of Hedera rhombea Bean

Abstract

A new C₁₇-polyacetylene, named hederyne A (1), has been isolated from the MeOH extract of galls of Hedera rhombea Bean (Araliaceae), together with two known polyacetylenes, falcarindiol (2) and 11,12-dehydrofalcarinol (3). The structure elucidation of 1 was achieved by NMR, MS, IR, and UV spectroscopy. Hederyne A (1) was a new C₁₇-diacetylene containing 1,3-propanediol and exhibited selective antimicrobial activity against Micrococus luteus.

Keywords:

• Hedera rhombea Bean
• Polyacetylenes
• Gall
• Hederyne A
• Antimicrobial activity

Acknowledgements

We thank Dr M. Tokuda (National Institute of Advanced Industrial Science and Technology) for collection and identification of the galls. This work was partly supported by Grants-in-Aid for the Naito foundation, and University of Tsukuba Projects.