A new anti-HIV lupane acid from Gleditsia sinensis Lam.

Abstract

A new lupane acid, 2β-carboxyl,3β-hydroxyl-norlupA (1)-20 (29)-en-28-oic acid (1), together with five known lupane acid derivatives (2–6), were isolated from the stings of Gleditsia sinensis Lam.. Their structures were elucidated on the basis of 1D and 2D NMR techniques. All these known compounds were isolated from this genus for the first time. The new compound 1 showed strong anti-HIV activity.

Keywords:

• Gleditsia sinensis
• 2β-Carboxyl,3β-hydroxyl-norlupA(1)-20 (29)-en-28-oic acid
• Lupane acid
• Anti-HIV activity

Acknowledgements

This work was supported by NKIP Foundation of CAS (KSCZX-SW-301-08), “Xibuzhiguang” Union Lab. Program and Foundation of Key State Lab of Phytochemistry. The authors are grateful to the Analytical Group of the Laboratory of Phytochemistry, Kunming Institute of Botany, CAS, for the spectral measurements.