Two novel isosteroid alkaloids from Fritillaria monatha

Abstract

Two new isosteroid alkaloids, N-methyl-22,26-imino-13,22-oxido-5α,20α-jervine-3β-ol-6-one, pengbeimine B (1) and N-methyl-22,26-imino-13,22-oxido-5α,20β-jervine-3β-ol-6-one, pengbeimine D (2) were isolated from the fresh bulbs of Fritillaria monatha Migo. Their structures were determined by spectral methods, and were proved by X-ray diffraction.

Keywords:

• Fritillaria monatha
• Isosteroid alkaloid
• Pengbeimine B
• Pengbeimine D

Acknowledgements

The work was financially supported by The National Natural Science Foundation of China (No. 30160097). The authors are grateful to Professor Cui Sheng Fan and Mr. Lan Cao for collecting experimental material. All spectra were recorded by the analytical group in The Institute of Material Medical, Chinese Academy of Medical Sciences.