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Original Articles

Microbial transformation of neoandrographolide by Aspergillus niger (AS 3.739)

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Pages 463-469 | Received 15 May 2006, Accepted 07 Jul 2006, Published online: 27 Jul 2010
 

Abstract

The biotransformation of neoandrographolide (1) was investigated by using Aspergillus niger (AS 3.739). Five products were obtained and identified as 8(17),13-ent-labdadien-16,15-olid-19-oic acid (2), 19-hydroxy-8(17),13-ent-labdadien-16,15-olide (3), 18-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (4), 3α-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (5) and 8β,19-dihydroxy-ent-labd-13-en-16,15-olide (6) by spectroscopic and chemical means. Products 4, 5 and 6 are new compounds.

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