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Abstract
Two new lanostane triterpenoids, 3-epipachymic acid (3α-acetoxy-16α-hydroxy-24-methylene-5α-lanost-8-en-21-oic acid, 1) and 3α-(3-hydroxy-5-methoxy-3-methyl-1,5-dioxopentyloxy)-24-methylene-5α-lanost-8-en-21-oic acid (2), together with a known compound, 3-oxo-5α-lanosta-8,24-dien-21-oic acid (3), were isolated from the fruiting body of Ganoderma resinaceum. The structure elucidation was accomplished by spectroscopic methods, especially NMR experiments. Compound 2 showed significant cytotoxic activity with IC50 value of 2.5 μg/ml in Hep-2 cell line.