Synthesis and allylation at the all O-6 positions of cyclomaltohexaose

Abstract

A method for preparation of per-6-O-substituted cyclodextrin derivatives was developed. The thermostable cyclomaltodextrin glucanotransferase (CGTase) formed mainly cyclomaltohexaose 2 from amylose 1. The compound 2 was selectively converted to 3 without protection of the other hydroxyl groups by allylation at the all O-6 positions in excess base.

Keywords:

• Cyclomaltodextrin glucanotransferase
• Hexakis (6-O-allyl)cyclomaltohexaose
• Synthesis
• Allylation