A novel alkaloid from the fruits of Evodia officinalis

Abstract

Studies on the fruits of Evodia officinalis yielded a new quinazolinedione alkaloid, wuchuyuamide III (1), together with known alkaloids, goshuyuamide II (2), evodiamine and rutaecarpine. Their structures were elucidated by means of 1D and 2D NMR spectroscopic analysis. Wuchuyuamide III (1) and goshuyuamide II (2) showed modest cytotoxicity against HeLa and HT1080 cell lines.

Keywords:

• Evodia officinalis
• Wuchuyuamide
• Goshuyuamide
• Cytotoxicity

Acknowledgements

This work was supported in part by a grant from Korea Research Institute of Bioscience and Biotechnology Research Initiative Program and a research grant (PF0320701-00) from Plant Diversity Research Centre of 21st Frontier Research Program funded by the Korean Ministry of Science and Technology.