Gerardianin A, a new abietane diterpenoid from Isodon lophanthoides var. gerardianus

Abstract

A new abietane diterpenoid, gerardianin A (1), along with a known compound 6,7-dehydroroyleanone (2), has been isolated from the aerial parts of Isodon lophanthoides var. gerardianus [Bentham] H. Hara. The structure of 1 was determined on the basis of spectroscopic methods and X-ray single-crystal diffraction analysis.

Keywords:

• Isodon lophanthoides var. gerardianus
• diterpenoid
• NO production inhibitory activity
• gerardianin A

Acknowledgements

This work was supported by a grant from the National Natural Science Foundation (No. 30672596) of China, and the Key Natural Science Foundation of Guangdong Province (No. 36575). We thank Professor J.-N. Chen of New Drug R&D Center, Guangzhou University of Chinese Medicine, for identification of the plant species.