Microbial transformation of alantolactone by Mucor polymorphosporus

Xiu-Lan Xin The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China; Beijing Vocational College of Electronic Science and Technology, Biotechnology Application Center, Beijing, China

Xiao-Chi Ma School of Pharmaceutical Sciences, Dalian Medical University, Dalian, ChinaCorrespondence[email protected]

Ke-Xin Liu School of Pharmaceutical Sciences, Dalian Medical University, Dalian, China

Jian Han The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China

Bao-Rong Wang The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China

De-An Guo The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China

Abstract

Two new transformed sesquiterpenes of alantolactone by Mucor polymorphosporus were obtained. They were characterized as 3β-hydroxy-11βH-eudesm-5-en-8β,12-olide (2) and 3β,11α-dihydroxy-eudesm-5-en-8β,12-olide (3), on the basis of spectral methods including 2D NMR. And product 3 was an unusual hydroxylation derivative of alantolactone at C-11.

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Acknowledgements

We thank the Youth Foundation (30701088) by National Natural Science Foundation of China and PHR (IHLB) for financial support.

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Microbial transformation of alantolactone by Mucor polymorphosporus

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Microbial transformation of alantolactone by Mucor polymorphosporus

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