The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist

Abstract

Four nitrogen-containing derivatives of ginkgolide B were synthesized to improve the physical–chemical properties and bioavailability of ginkgolide B. The reaction was accomplished with the nitrogen atom as neighboring group participating in the replacement reaction. All of the four compounds were proved to have excellent inhibiting effect on rabbit platelet aggregation induced by platelet-activating factor which is as well as ginkgolide B.

Keywords:

• ginkgolide B
• nitrogen-containing groups
• anti-PAF
• participation of neighboring nitrogen atom

Acknowledgements

This work was partially supported by the Undergraduate Student Scientific and Innovation Foundation of the School of Pharmacy, Fudan University, Republic of China (KC200622).