Synthesis and enantiomeric resolution of (±)-pinocembrin

Yue Yuan Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Qing-Yun Yang Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Yuan-Feng Tong Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Feng Chen Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Yan Qi Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Ya-Bo Duan Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Song Wu Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, ChinaCorrespondence[email protected]

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Abstract

A convenient method for the synthesis and enantiomeric resolution of ( ± )-pinocembrin has been developed. This route involves the hydrogenation of 5,7-dihydroxyflavone, the derivatization of racemic pinocembrin with chiral amine, and the separation of the diastereoisomers due to their different physical properties.

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Synthesis and enantiomeric resolution of (±)-pinocembrin

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Synthesis and enantiomeric resolution of (±)-pinocembrin

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